1259014-67-9

Upstream product

• 60934-84-1 (1,4,4-trimethylcyclohex-2-en-1-ol) 
• 1073-13-8 4,4-dimethylcyclohexenone 
• 1259014-66-8 methyl 3-(1-hydroxy-2,2,5,5-tetramethylcyclohexyl)propiolate 

Downstream Products

• 1259014-68-0 (E)-methyl 3-(3,3,6,6-tetramethylcyclohex-1-enyl)acrylate 
• 1259014-69-1 (E)-3-(3,3,6,6-tetramethylcyclohex-1-enyl)acrylic acid 
• 1259013-86-9 (E)-1-morpholino-3-(3,3,6,6-tetramethylcyclohex-1-enyl)prop-2-en-1-one 
• 1259013-87-0 (E)-4-(3-(3,3,6,6-tetramethylcyclohex-1-enyl)acryloyl)piperazine-1-carboxamide 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.