1259015-07-0

Basic information

• Product Name: 3-bromo-1-methylphenazine
• Synonyms: 3-bromo-1-methylphenazine
• CAS NO: 1259015-07-0
• Molecular Weight: 273.132
• Mol File: 1259015-07-0.mol

Chemical Properties

• CAS DataBase Reference: 3-bromo-1-methylphenazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-1-methylphenazine(1259015-07-0)
• EPA Substance Registry System: 3-bromo-1-methylphenazine(1259015-07-0)

Safety Data

• Hazardous Substances Data: 1259015-07-0(Hazardous Substances Data)

Upstream product

• 583-63-1 ortoquinone 
• 76153-06-5 5-bromo-3-methylbenzene-1,2-diamine 

Relevant articles and documents

Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from streptomyces species, strain CNS284

The isolation of 2-bromo-1-hydroxyphenazine from a marine Streptomyces species, strain CNS284, and its activity against NF-κB, suggested that a short and flexible route for the synthesis of this metabolite and a variety of phenazine analogues should be developed. Numerous phenazines were subsequently prepared and evaluated as inducers of quinone reductase 1 (QR1) and inhibitors of quinone reductase 2 (QR2), NF-κB, and inducible nitric oxide synthase (iNOS). Several of the active phenazine derivatives displayed IC50 values vs QR1 induction and QR2 inhibition in the nanomolar range, suggesting that they may find utility as cancer chemopreventive agents.