1259178-91-0Relevant academic research and scientific papers
A myosin-V inhibitor based on privileged chemical scaffolds
Islam, Kabirul,Chin, Harvey F.,Olivares, Adrian O.,Saunders, Lauren P.,De-la-cruz, Enrique M.,Kapoor, Tarun M.
supporting information; experimental part, p. 8484 - 8488 (2010/12/29)
Switching the motor off: Privileged chemical scaffolds were used as a starting point for the development of a specific chemical inhibitor 1 of myosin-V, a key motor protein required for intracellular transport (see picture; ADP=adenosine diphosphate, ATP=adenosine triphosphate). The potency of 1, which does not compete directly with nucleotide binding, is comparable to that of other known motor-protein inhibitors used as probes in chemical biology.
