125926-71-8

Basic information

• Product Name: [2-(3,5-Dichloro-phenyl)-pyrimidin-4-yl]-hydrazine
• Synonyms: [2-(3,5-Dichloro-phenyl)-pyrimidin-4-yl]-hydrazine
• CAS NO: 125926-71-8
• Molecular Weight: 255.106
• Mol File: 125926-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(3,5-Dichloro-phenyl)-pyrimidin-4-yl]-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(3,5-Dichloro-phenyl)-pyrimidin-4-yl]-hydrazine(125926-71-8)
• EPA Substance Registry System: [2-(3,5-Dichloro-phenyl)-pyrimidin-4-yl]-hydrazine(125926-71-8)

Safety Data

• Hazardous Substances Data: 125926-71-8(Hazardous Substances Data)

Upstream product

• 131851-89-3 3,5-Dichloro-benzimidic acid methyl ester; hydrochloride 
• 125903-94-8 2-(3,5-Dichloro-phenyl)-3H-pyrimidin-4-one 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 125904-08-7 4-Chloro-2-(3,5-dichloro-phenyl)-pyrimidine 

Downstream Products

• 125927-01-7 5-(3,5-Dichloro-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-2-ylamine 

Relevant articles and documents

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.