1259278-17-5

Basic information

• Product Name: (1r,3s)-3-amino-1-(boc-amino)cyclohexane
• Synonyms: (1r,3s)-3-amino-1-(boc-amino)cyclohexane;tert-Butyl ((1R,3S)-3-aminocyclohexyl)carbamate
• CAS NO: 1259278-17-5
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.30458
• Mol File: 1259278-17-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 322.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.02±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.40±0.40(Predicted)
• CAS DataBase Reference: (1r,3s)-3-amino-1-(boc-amino)cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: (1r,3s)-3-amino-1-(boc-amino)cyclohexane(1259278-17-5)
• EPA Substance Registry System: (1r,3s)-3-amino-1-(boc-amino)cyclohexane(1259278-17-5)

Safety Data

• Hazardous Substances Data: 1259278-17-5(Hazardous Substances Data)

Usage

General Description

(1R,3S)-3-amino-1-(Boc-amino)cyclohexane is a chemical compound with the molecular formula C10H20N2O2. It is a cyclohexane derivative with an amino group and a Boc-protected amino group attached to the carbon atoms at positions 3 and 1, respectively. The compound is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and structural properties. Additionally, the Boc (tert-butyloxycarbonyl) protecting group can be easily removed under mild conditions, making it a valuable intermediate in organic synthesis. The compound's stereochemistry, with a cis-1,3 relationship between the two functional groups, also contributes to its usefulness in organic chemistry.

Upstream product

• 222530-34-9 (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid 
• 1223158-00-6 benzyl cis-3-(aminocyclohexyl)carbamate 
• 498532-32-4 C₆H₁₄N₂*2ClH 
• 3385-21-5 1,3-diaminocyclohexane 
• 62059-56-7 cis-1,3-Cyclohexanedicarboxylic acid diethyl ester 
• 4355-31-1 3-oxabicyclo<3.3.1>nonane-2,4-dione 
• 2305-30-8 (1R)-cyclohexane-1,3-dicarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1261225-48-2 [3-(1S,3R)-benzyloxycarbonylaminocyclohexyl]-1-carbamic acid tertbutyl ester 
• 1259278-12-0 benzyl N-[(1S,3R)-3-aminocyclohexyl]carbamate 
• 1259278-11-9 benzyl N-[(1S,3R)-3-carbamoylcyclohexyl]carbamate 
• 952616-39-6 (1R,3S)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid 
• 1259278-09-5 ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexane-1-carboxylate 
• 227783-08-6 (1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid 

Downstream Products

• 1298101-49-1 C₂₈H₃₅N₅O₅ 
• 1383485-60-6 C₁₆H₂₂BrF₂N₃O₂ 
• 1383485-61-7 (1S,3R)-N₁-(6-bromo-3,5-difluoropyridin-2-yl)cyclohexane-1,3-diamine 
• 1259278-16-4 tert-butyl N-[(1R,3S)-3-[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]carbamate 
• 1259279-59-8 tert-butyl N-[(1R,3S)-3-[[5-fluoro-2-[5-fluoro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]amino]cyclohexyl]carbamate 
• 1259278-24-4 N-[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]-2-m ethoxy-acetamide 
• 1259278-50-6 (1S,3R)-N₁-[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]cyclohexane-1,3-diamine 
• 1259278-19-7 N-[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]acetamide 

Relevant articles and documents

BCAT MODULATION

This disclosure relates to, in part, the treatment of an organic acidemia in a subject in need thereof via administration of a therapeutically effective amount of compounds that inhibit BCAT2. The disclosure also relates to, in part, methods for identifying a candidate compound for treatment of organic acidemias.

Development of a Scalable Synthesis of an Azaindolyl-Pyrimidine Inhibitor of Influenza Virus Replication

A scalable, asymmetric route for the synthesis of the influenza virus replication inhibitor 2 is presented. The key steps include an enzymatic desymmetrization of cis-1,3-cyclohexanediester in 99% yield and 96% ee, SNAr displacement of a methanesulfinylpyrimidine, and a Curtius rearrangement to form a morpholinyl urea. This high-yielding route allowed us to rapidly synthesize hundreds of grams of 2 in 99% purity to support in vivo studies.

SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to process of preparation of these pyrimidine compounds, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders mediated by epidermal growth factor receptor (EGFR) family kinases.