1259296-46-2 Usage
Description
MPI5a is a compound with various applications in different industries, particularly due to its unique properties and characteristics.
Uses
Used in Pharmaceutical Industry:
MPI5a is used as an HDAC6 Inhibitor for its potent and selective inhibition of HDAC6, which poorly blocks other HDAC enzymes. This makes it a valuable compound in the development of targeted therapies for various diseases.
Used in Cancer Research:
MPI5a is used as a research tool for studying the role of HDAC6 in cancer biology. By inhibiting HDAC6, researchers can gain insights into the molecular mechanisms underlying cancer development and progression, potentially leading to the discovery of novel therapeutic strategies.
Used in Drug Development:
MPI5a is used as a starting point for the development of new drugs targeting HDAC6. Its potent and selective inhibition of HDAC6 makes it an attractive candidate for further optimization and development into a more effective and safer drug for treating various diseases, including cancer.
Used in Drug Delivery Systems:
MPI5a can be used in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of HDAC6 inhibitors. By incorporating MPI5a into novel drug delivery systems, such as nanoparticles or other carriers, its efficacy and delivery can be enhanced, potentially leading to better treatment options for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1259296-46-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,9,2,9 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1259296-46:
(9*1)+(8*2)+(7*5)+(6*9)+(5*2)+(4*9)+(3*6)+(2*4)+(1*6)=192
192 % 10 = 2
So 1259296-46-2 is a valid CAS Registry Number.
1259296-46-2Relevant articles and documents
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform
Blackburn, Christopher,Barrett, Cynthia,Chin, Janice,Garcia, Kris,Gigstad, Kenneth,Gould, Alexandra,Gutierrez, Juan,Harrison, Sean,Hoar, Kara,Lynch, Chrissie,Rowland, R. Scott,Tsu, Chris,Ringeling, John,Xu, He
, p. 7201 - 7211 (2013/10/21)
A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.
