1259372-69-4

Basic information

• Product Name: VU0155041 sodium salt
• Synonyms: VU0155041 sodium salt;cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacidsodiumsalt
• CAS NO: 1259372-69-4
• Molecular Formula: C14H14Cl2NNaO3
• Molecular Weight: 338.16163
• Product Categories: Glutamate
• Mol File: 1259372-69-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Desiccate at RT
• CAS DataBase Reference: VU0155041 sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: VU0155041 sodium salt(1259372-69-4)
• EPA Substance Registry System: VU0155041 sodium salt(1259372-69-4)

Safety Data

• Hazardous Substances Data: 1259372-69-4(Hazardous Substances Data)

Usage

Description

VU0155041 sodium salt is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with a selective action and potential neuroprotective properties. It is characterized by its ability to modulate glutamate response and its lack of antagonist activity at NMDA receptors, making it a promising candidate for various neurological applications.

Uses

Used in Pharmaceutical Industry:
VU0155041 sodium salt is used as a neuroprotective agent for providing functional neuroprotection in 6-hydroxydopamine rat models with Parkinson's disease. It helps in decreasing catalepsy induced by haloperidol and reversing askinesias induced by reserpine, making it a potential therapeutic option for Parkinson's disease treatment.
Additionally, VU0155041 sodium salt is used as a therapeutic agent for restoring social behavior in the Oprm-/mouse model of autism. It demonstrates the ability to increase the percentage of time spent in the open arms of the elevated plus maze, indicating its potential in addressing anxiety-related conditions.
Furthermore, due to its selectivity and lack of antagonist activity at NMDA receptors, VU0155041 sodium salt can be utilized in the development of novel drug delivery systems and therapeutic strategies for various neurological disorders, including Parkinson's disease and autism.