125941-87-9 Usage
Description
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride is a complex organic compound with a specific molecular structure that features a benzazepine core, a chlorine atom at the 7th position, a hydroxyl group at the 8th position, a methyl group at the 3rd position, and a phenyl group at the 1st position. It is a hydrochloride salt, which indicates that it is a salt form of the parent compound, likely improving its solubility and stability.
Uses
Used in Pharmaceutical Industry:
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride is used as a selective dopamine D1 receptor antagonist for various applications in the pharmaceutical industry. Its primary use is to modulate the activity of the dopamine D1 receptor, which plays a crucial role in the central nervous system and is implicated in various neurological and psychiatric disorders.
Used in Research and Development:
In the field of research and development, R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride is utilized as a D1 receptor-selective antagonist for intracranial drug infusions. This application allows researchers to study the specific effects of blocking the D1 receptor on various cognitive and behavioral processes.
Used in Preclinical Studies:
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride is also used for intraperitoneal injection into experimental rats to study the role of the D1 receptor in sensitization. This helps researchers understand the receptor's involvement in the development of certain conditions and the potential therapeutic benefits of targeting this receptor.
Used in Neuropharmacology:
In the field of neuropharmacology, R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride serves as an antagonist of the D1 receptor to study its effect on learning ability in fish. This application provides valuable insights into the receptor's role in cognitive functions and the potential for developing new treatments for cognitive disorders.
Biological Activity
Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .
Biochem/physiol Actions
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 125941-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,9,4 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125941-87:
(8*1)+(7*2)+(6*5)+(5*9)+(4*4)+(3*1)+(2*8)+(1*7)=139
139 % 10 = 9
So 125941-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
