1259513-65-9

Basic information

• Product Name: 1-(3-methyl-2-phenyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran]
• Synonyms: 1-(3-methyl-2-phenyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran]
• CAS NO: 1259513-65-9
• Molecular Weight: 491.633
• Mol File: 1259513-65-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-methyl-2-phenyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran](CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methyl-2-phenyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran](1259513-65-9)
• EPA Substance Registry System: 1-(3-methyl-2-phenyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran](1259513-65-9)

Safety Data

• Hazardous Substances Data: 1259513-65-9(Hazardous Substances Data)

Upstream product

• 64495-56-3 4-chloro-3-methyl-2-phenylquinoline 
• 1259512-05-4 6-morpholino-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran] 
• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 
• 1202765-53-4 methyl 4-(4-bromo-2-nitrophenyl)tetrahydro-2H-pyran-4-carboxylate 
• 1190861-43-8 6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one 
• 1202765-56-7 6-bromo-2',3',5',6'-tetrahydrospiro[dihydroindole-3,4'-pyran] 

Relevant articles and documents

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors

Structure-based rational design led to the synthesis of a novel series of potent PI3K inhibitors. The optimized pyrrolopyridine analogue 63 was a potent and selective PI3Kβ/δ dual inhibitor that displayed suitable physicochemical properties and pharmacokinetic profile for animal studies. Analogue 63 was found to be efficacious in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis (CIA) disease model of rheumatoid arthritis. These studies highlight the potential therapeutic value of inhibiting both the PI3Kβ and δ isoforms in the treatment of a number of inflammatory diseases.