1259568-28-9Relevant articles and documents
Indazole derivatives as novel bradykinin B1 receptor antagonists
Bodmer-Narkevitch, Vera,Anthony, Neville J.,Cofre, Victoria,Jolly, Samson M.,Murphy, Kathy L.,Ransom, Richard W.,Reiss, Duane R.,Tang, Cuyue,Prueksaritanont, Thomayant,Pettibone, Douglas J.,Bock, Mark G.,Kuduk, Scott D.
scheme or table, p. 7011 - 7014 (2010/12/29)
A new class of indazole-derived bradykinin B1 antagonists and their structure-activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B1 receptor and possess acceptable P-gp and pharmacokinetics properties.
