125968-89-0Relevant academic research and scientific papers
NAPHTHYRIDINE DERIVATIVES AS PRC2 INHIBITORS
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Paragraph 0227-0228, (2020/11/03)
Disclosed are compounds of formula (I) or (II) that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Pyridazines. XLI Synthesis of Novel Pyridopyridazine Derivatives from 4,5-Disubstituted Pyridazines
Boamah, Philip Yaw,Haider, Norbert,Heinisch, Gottfried
, p. 933 - 939 (2007/10/02)
Pyridopyridazines 2-5, 21 bearing one, two, or three aryl substituents in the pyridine moiety are shown to be conveniently accessible from 4-aroyl-5-methylpyridazines or 4,5-diaroylpyridazines, respectively, by condensation reactions with appropriate C-N fragments.In addition, the novel pyridazine-annelated pyridones 24, 25 were found to be easily available from ethyl 5-methyl-4-pyridazinecarboxylate.
