125983-71-3

Upstream product

• 104688-93-9 (4-Methoxy-phenylamino)-oxo-dithioacetic acid methyl ester 
• 62-53-3 aniline 
• 4955-82-2 1-cyanothioformanilide 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 252005-05-3 5-imino-2-methyl-3-phenyl-oxazolidine-4-thione 
• 104-94-9 4-methoxy-aniline 
• 252005-08-6 2-methyl-3-phenyl-4-thioxo-oxazolidin-5-one 

Downstream Products

• 114370-73-9 5-Chloromethyl-4-phenyl-4H-[1,2,4]triazole-3-carboxylic acid (4-methoxy-phenyl)-amide 
• 132349-87-2 C₁₅H₁₆N₄O₂ 

Relevant academic research and scientific papers

A comparative study of 4-thioxo-(imidazolidines and oxazolidines) and some nucleophilic reagents

The imidazolidines (II) were reacted with amines, H2S and ?-phenylenediamines to give 4-substituted imino derivatives (VI), thiohydantoin (VII) and 1-phenyl-3 -substituted-1H-imidazo[4,5-b]-quinoxaline-2-(3H)-ones(XIII), respectively. Interaction of the oxazolidines (V) with amines, ?-phenylenediamines and ?-aminophenol caused fission of the oxazole ring to produce (XIV, XVII & XIX) respectively.

Dithiocarboxylic Acids, Dithiocarboxylic Esters, or Thiocarboxylic Amides by Reaction of Methylene-active Chloromethyl Compounds with Sulfur

With a mixture of sulfur and amine in DMF at room temperature halomethyl compounds (1,5-10) can be oxidized to give thiocarboxylic acids (2,11-16) and their derivatives (3,4,17-35).We studied this reaction in detail especially with chloroacetic derivatives (11-15) or chloromethyl heterocycles (16) formally derived from chloroacetic acid.The resulting thiooxalic acid derivatives (11-27) represent activated acids and very useful C2-synthons, especially for the synthesis of heterocycles.Oxidation in the presence of triethylamine leads to dithiocarboxylates (11-16) which can be alkylated to dithioesters (17-27) in high yields.As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides (28-35).