1259890-95-3Relevant academic research and scientific papers
Site-selective cross-coupling of dichlorinated benzo-fused nitrogen-heterocycles with Grignard reagents
Konishi, Hideyuki,Itoh, Tatsuya,Manabe, Kei
experimental part, p. 1255 - 1258 (2010/11/05)
Site-selective cross-coupling of dihaloarenes constitutes a useful method for synthesis of multi-substituted arenes. In this paper, we report the site-selective cross-coupling of dichlorinated benzo-fused nitrogen-heterocycles having two chloro groups on the benzene ring. These dichlorinated heterocycles reacted with Grignard reagents in the presence of PdCl2(PCy 3)2 at the positions ortho to the nitrogen-based substituents with high selectivities. A mechanism in which interaction between Lewis acidic Mg and Cl of the ortho position facilitates C-Cl bond cleavage is proposed.
