1259930-90-9Relevant academic research and scientific papers
Administration of ferrocene-modified amino acids induces changes in synaptic transmission in the CA1 area of the hippocampus
Dobryakova, Yulia V.,Ilyin, Mikhail M.,Markevich, Vladimir A.,Rodionov, Alexey N.,Simenel, Alexander A.,Snegur, Lubov V.
, (2020/01/24)
A series of ferrocene-modified amino acid methyl esters with pyrazole linker was prepared in good to quantitative yields starting from easy accessible ferrocene pyrazole carbaldehyde and amino acids in racemic and enantio enriched forms under reductive amination conditions (NaBH (OAc)3, reflux, 3 hr). The resulting enantiomers were resolved using analytical HPLC on modified cellulose or amylose as chiral selectors. In vivo electrophysiological experiments were performed in the CA1 field of the hippocampus on 3a Fc-Gly, (L)-3b Fc-Ala, and (D)-3b Fc-Ala compounds. An increasing in the amplitudes of responses of local potentials (up to 25%) of the CA1 region in the studied groups was found after intraperitoneal administration of ferrocene compounds 3a and (D)-3b compared with control rats treated with saline.
Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus
Rodionov,Snegur,Simenel,Dobryakova, Yu. V.,Markevich
, p. 136 - 142 (2017/07/05)
A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established.
