1259946-33-2Relevant academic research and scientific papers
Induction of chirality: Experimental evidence of atropisomerism in azapeptides
Ottersbach, Philipp A.,Schnakenburg, Gregor,Guetschow, Michael
supporting information; experimental part, p. 5772 - 5774 (2012/08/28)
Methylation of the peptide bond in model azadipeptides leads to the E configuration and hence to atropisomerism due to a restricted rotation around the N-N axis. This journal is
Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors
Frizler, Maxim,Lohr, Friederike,Furtmann, Norbert,Kl?s, Julia,Gütschow, Michael
supporting information; experimental part, p. 396 - 400 (2011/03/18)
Using the example of cathepsin K, we demonstrate the design of highly potent and selective azadipeptide nitrile inhibitors. A systematic scan with respect to P2 and P3 substituents was carried out. Structural modifications strongly affected the enzyme-inh
