1259948-53-2

Upstream product

• 1259948-49-6 2-[(2-bromobenzyl)sulfonyl]benzo[d]thiazole 
• 2492-26-4 sodium 2-mercaptobenzothiazole 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 1259948-66-7 4-[2-(2-bromophenyl)-2-fluorovinyl]pyridine 
• 1259948-63-4 1-bromo-2-{1-fluoro-2-[2-(trifluoromethyl)phenyl]vinyl}benzene 
• 1259948-64-5 1-bromo-2-{1-fluoro-2-[2-(trifluoromethyl)phenyl]vinyl}benzene 
• 1259948-65-6 (E)-3-[2-(2-bromophenyl)-2-fluorovinyl]-2-chloropyridine 
• 1372763-50-2 1-bromo-2-(1-fluorovinyl)benzene 

Relevant academic research and scientific papers

Expedient synthesis of α-substituted fluoroethenes

A mild and efficient synthesis of 1-aryl-1-fluoroethenes from benzothiazolyl (aryl)fluoromethyl sulfones and paraformaldehyde, under DBU- or Cs2CO3-mediated conditions at room temperature, is described. A comparable diethyl fluoro(naphthalen-2-yl)methylphosphonate reagent does not react with paraformaldehyde under these mild conditions. The utility of the methodology for synthesis of terminal α-fluoroalkenes bearing electron-withdrawing functionalities is also shown.

Novel aromatic fluoroolefins via fluoro-Julia-Kocienski olefination

Fluoroolefins, which play an increasingly important role as peptide mimics in pharmaceuticals and as crop protection agents, are generated using a fluoro-Julia-Kocienski olefination. Their preparation can easily be accomplished using a Mitsunobu reaction and subsequent oxidation to generate the required benzothiazolyl sulfones. The key step of this process was the electrophilic -fluorination of the sulfone with N-fluorobenzenesulfonimide. The last stage of the successful synthesis of the fluoroolefins was the modified Julia-Kocienski olefination under basic conditions. Further functionalization was followed with the application of a Suzuki reaction. Georg Thieme Verlag Stuttgart.