126-92-1

Basic information

• Product Name: Sodium 2-ethylhexyl sulfate
• Synonyms: 08-unioncarbide;1-hexanol,2-ethyl-,hydrogensulfate,sodiumsalt;2-ethyl-1-hexanolhydrogensulfatesodiumsalt;2-ethyl-1-hexanolsodiumsulfate;2-ethyl-1-hexanolsulfatesodiumsalt;2-ethylhexylsiransodny;2-ethylhexylsodiumsulfate;2-ethylhexylsulfatesodium
• CAS NO: 126-92-1
• Molecular Formula: C₈H₁₇O₄S*Na
• Molecular Weight: 232.27
• EINECS: 204-812-8
• Product Categories: INORGANIC & ORGANIC CHEMICALS
• Mol File: 126-92-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 148-149 °C
• Appearance: clear, colorless, slightly viscous liquid
• Density: 1.12 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.2Pa at 20℃
• Storage Temp.: Store at RT.
• Solubility: DMSO (Soluble), Water (Soluble)
• Water Solubility: >=10 g/100 mL at 20 ºC
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 5177087
• CAS DataBase Reference: Sodium 2-ethylhexyl sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium 2-ethylhexyl sulfate(126-92-1)
• EPA Substance Registry System: Sodium 2-ethylhexyl sulfate(126-92-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 1
• Hazardous Substances Data: 126-92-1(Hazardous Substances Data)

Usage

Chemical Properties

solid

Uses

Different sources of media describe the Uses of 126-92-1 differently. You can refer to the following data:
1. Detergent.
2. Sodium 2-Ethylhexyl Sulfate Hydrate (40% in Water) can be used for stable aqueous suspension formulations.
3. Sodium 2-ethylhexyl sulfate is an anionic surfactant that can be used:In suspension polymerization.In the analysis of phenolic compounds through microchip-CE with pulsed amperometric detection.As charge balancing anions in the synthesis of organo-layered double hydroxides (organo-LDHs).

General Description

Clear, colorless, slightly viscous liquid.

Air & Water Reactions

Water soluble.

Fire Hazard

Sodium 2-ethylhexyl sulfate is probably nonflammable.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and skin contact. A skin and eye irritant. A combustible liquid. When heated to decomposition it emits very toxic fumes of SOx and Na2O.

InChI:InChI=1/C8H18O4S/c1-3-5-6-8(4-2)7-12-13(9,10)11/h8H,3-7H2,1-2H3,(H,9,10,11)/p-1

Synthetic route

2-Ethylhexyl alcohol (104-76-7) → sodium 2-ethylhexyl sulfate (126-92-1)

Conditions	Yield
Stage #1: 2-Ethylhexyl alcohol With pyridine; aminosulfonic acid at 95℃; for 16h; Microwave irradiation; Stage #2: With sodium carbonate In methanol; water at 20℃; for 0.5h; Stage #3: With sodium sulfate In methanol; water at 20℃; for 0.333333h;

cinnarizine hydrochloride (880764-36-3) + sodium 2-ethylhexyl sulfate (126-92-1) → cinnarizine 2-ethyl-1-hexyl sulfate

Conditions	Yield
In dichloromethane; water at 20℃;

lumefantrine hydrochloride + sodium 2-ethylhexyl sulfate (126-92-1) → lumefantrine 2-ethyl-1-hexylsulfate

Conditions	Yield
In dichloromethane; water at 20℃; Darkness;

Upstream product

• 104-76-7 2-Ethylhexyl alcohol 

Relevant articles and documents

API ionic liquids: Probing the effect of counterion structure on physical form and lipid solubility

Lipid based formulations (LBFs) are extensively utilised as an enabling technology in drug delivery. The use of ionic liquids (ILs) or lipophilic salts (LS) in drug delivery has also garnered considerable interest due to unique solubility properties. Conversion of active pharmaceutical ingredients (API) to ILs by pairing with an appropriately lipophilic counterion has been shown to decrease melting point of the salt complex and improve solubility in LBFs. However, the relationship between the structure of the counterion, the physicochemical properties of the resulting salts and solubility in LBFs has not been systematically explored. This study investigates the relationship between alkyl sulfate counterion structure and melting temperature (Tm or Tg) in addition to LBF solubility, utilizing cinnarizine and lumefantrine as model weakly basic APIs. Three series of structurally diverse alkyl sulfate counterions were chosen to probe this relationship. Pairing cinnarizine and lumefantrine with a majority of these alkyl sulfate counterions resulted in a reduction in melting temperature and enhanced solubility in model medium chain and long chain LBFs. The chain length of the alkyl sulfate plays a crucial role in performance, and consistently branched alkyl sulfate counterions perform better than straight chain alkyl sulfate counterions, as predicted. Most interestingly, trends in counterion performance were found to be consistent across two APIs with disparate chemical structures. The findings from this study will facilitate the design of counterions which enhance solubility of ionisable drugs and unlock the potential to develop compounds previously restrained by poor solubility.