1260017-94-4Relevant articles and documents
Discovery of potent α1L-adrenoceptor agonists: Design and synthesis of bicyclic derivatives
Suzuki, Shinya,Okano, Tsubasa,Horiuchi, Rie,Hareyama, Nana,Amikura, Kazutoshi,Yamamoto, Naoyoshi,Yoshizawa, Yoshitaka,Yagi, Mai,Serizawa, Kanako,Hayashi, Ryoji
, p. 3368 - 3372 (2015/07/08)
Abstract We aimed to create a novel and potent α1L-adrenoceptor agonist because such agonists are possible drug candidates for stress urinary incontinence. We used ligand-based drug design and evaluated the α1L-adrenoceptor agonist a
NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS
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Page/Page column 123, (2013/10/21)
The present invention relates to compounds of general formula (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.