1260021-81-5Relevant articles and documents
Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
East, James E.,Kennedy, Andrew J.,Tomsig, Jose L.,De Leon, Alexandra R.,Lynch, Kevin R.,MacDonald, Timothy L.
supporting information; experimental part, p. 7132 - 7136 (2010/12/25)
Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA's role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthe