1260029-45-5

Basic information

• Product Name: 3-acetoxy-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester
• Synonyms: 3-acetoxy-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester
• CAS NO: 1260029-45-5
• Molecular Weight: 290.239
• Mol File: 1260029-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetoxy-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetoxy-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester(1260029-45-5)
• EPA Substance Registry System: 3-acetoxy-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester(1260029-45-5)

Safety Data

• Hazardous Substances Data: 1260029-45-5(Hazardous Substances Data)

Upstream product

• 1253056-13-1 methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 108-24-7 acetic anhydride 

Downstream Products

• 1260029-44-4 (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester 

Relevant articles and documents

The asymmetric synthesis of Sitagliptin, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

An efficient asymmetric synthesis of Sitagliptin, a new DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been developed. The beta-amino acid fragment of Sitagliptin was prepared by asymmetric Michael addition of the corresponding α, β-unsaturated ester to (R)-(α-methylbenzyl) benzylamine followed by a two-step elaboration to obtain N-boc beta-amino ester. Hydrolysis of the ester and coupling with the triazolopiperazine afforded Sitagliptin after cleavage of the N-boc group and salt formation. The overall yield was 31% over nine steps.