126004-36-2Relevant articles and documents
Imidazole derivatives, process for production thereof, and use thereof
-
, (2008/06/13)
Disclosed are imidazole derivatives represented by formula [I]: STR1 wherein R is a hydrogen atom or STR2 wherein R2 is a hydrogen atom or a hydroxy protecting group, R2 protecting either a single hydroxy or two hydroxies together when R2 is a hydroxy protecting group, and R3 is a hydrogen atom or OR2 ; A is CONH2 or CN; and R1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl. Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position. Furthermore, the compounds having remarkable antitumor activities and therefore can provide novel antitumor agents.