1260071-96-2Relevant academic research and scientific papers
Nickel-catalyzed cyclization of difluoro-substituted 1,6-enynes with organozinc reagents through the stereoselective activation of c-f bonds: Synthesis of bicyclo[3.2.0]heptene derivatives
Takachi, Manabu,Kita, Yusuke,Tobisu, Mamoru,Fukumoto, Yoshiya,Chatani, Naoto
, p. 8717 - 8720 (2010)
Quite a gem: A nickel-catalyzed cyclization of 1,6-enynes, bearing a gem-difluoro group at the olefinic terminus, with organozinc reagents gives the title compounds (see scheme). One of the fluorine atoms is stereoselectively replaced by the R group of R
