1260086-02-9

Basic information

• Product Name: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline
• Synonyms: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline
• CAS NO: 1260086-02-9
• Molecular Weight: 288.75
• Mol File: 1260086-02-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(1260086-02-9)
• EPA Substance Registry System: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(1260086-02-9)

Safety Data

• Hazardous Substances Data: 1260086-02-9(Hazardous Substances Data)

Upstream product

• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1260086-11-0 methyl 3-chloro-2-hydroxypropyl(3-fluoro-4-morpholinophenyl)carbamate 
• 224323-50-6 linezolid 
• 333753-67-6 (dl)-N-[3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide 
• 1532560-87-4 (dl)-N-(3-amino-2-hydroxypropyl)-3-fluoro-4-morpholinylaniline 

Relevant articles and documents

First general route to substituted α-arylamino-α′ chloropropan-2-ones by oxidation of N-protected aminohalohydrins: The importance of disrupting hydrogen bond networks

The presence of a network of intra- and intermolecular hydrogen bonds in β-arylamino alcohols, confirmed by both IR spectroscopy and computer modeling, inhibits their oxidation to the corresponding α-amino ketones. A straightforward protocol, including highly regioselective protection (as carbamates) and subsequent oxidation with Dess-Martin periodinane, affords near quantitative yields of the desired N-protected ketones, which upon mild treatment with iodotrimethylsilane leads to a series of differently functionalized α-arylamino-α′-chloro ketones. Georg Thieme Verlag Stuttgart.