1260086-02-9

Basic information

• Product Name: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline
• Synonyms: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline
• CAS NO: 1260086-02-9
• Molecular Weight: 288.75
• Mol File: 1260086-02-9.mol

Chemical Properties

• CAS DataBase Reference: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(1260086-02-9)
• EPA Substance Registry System: (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline(1260086-02-9)

Safety Data

• Hazardous Substances Data: 1260086-02-9(Hazardous Substances Data)

Upstream product

• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1260086-11-0 methyl 3-chloro-2-hydroxypropyl(3-fluoro-4-morpholinophenyl)carbamate 
• 1532560-87-4 (dl)-N-(3-amino-2-hydroxypropyl)-3-fluoro-4-morpholinylaniline 
• 333753-67-6 (dl)-N-[3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide 
• 224323-50-6 linezolid 

Relevant articles and documents

First general route to substituted α-arylamino-α′ chloropropan-2-ones by oxidation of N-protected aminohalohydrins: The importance of disrupting hydrogen bond networks

The presence of a network of intra- and intermolecular hydrogen bonds in β-arylamino alcohols, confirmed by both IR spectroscopy and computer modeling, inhibits their oxidation to the corresponding α-amino ketones. A straightforward protocol, including highly regioselective protection (as carbamates) and subsequent oxidation with Dess-Martin periodinane, affords near quantitative yields of the desired N-protected ketones, which upon mild treatment with iodotrimethylsilane leads to a series of differently functionalized α-arylamino-α′-chloro ketones. Georg Thieme Verlag Stuttgart.

Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2

A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.