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Amino-PEG1-t-Butyl ester is a PEG reagent containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-Boc group can be deprotected under acidic conditions.

1260092-46-3

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1260092-46-3 Usage

Uses

Used in Pharmaceutical Industry:
Amino-PEG1-t-Butyl ester is used as a reagent for the preparation of β2 adrenergic receptor agonists and muscarinic receptor activity antagonists. Its hydrophilic PEG spacer and reactive amino group facilitate the synthesis of these pharmaceutical compounds, enhancing their solubility and reactivity in the development process.
Used in Chemical Synthesis:
Amino-PEG1-t-Butyl ester is used as a versatile building block in chemical synthesis. The t-Boc protected carboxyl group allows for selective deprotection under acidic conditions, enabling the synthesis of a wide range of PEGylated compounds with various functional groups.

Check Digit Verification of cas no

The CAS Registry Mumber 1260092-46-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,0,9 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1260092-46:
(9*1)+(8*2)+(7*6)+(6*0)+(5*0)+(4*9)+(3*2)+(2*4)+(1*6)=123
123 % 10 = 3
So 1260092-46-3 is a valid CAS Registry Number.

1260092-46-3Relevant academic research and scientific papers

Compound for targeted ubiquitination degradation of ERRalpha protein and pharmaceutical composition and application thereof

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Paragraph 0271-0272; 0282-0284, (2020/06/20)

The invention provides a compound with a structure shown as a formula (I), which has the effects of inhibiting ERRalpha protein activity and degrading ERRalpha protein activity, has relatively strongsubtype selectivity and can also effectively inhibit tri

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation

Peng, Lijie,Zhang, Zhensheng,Lei, Chong,Li, Shan,Zhang, Zhang,Ren, Xiaomei,Chang, Yu,Zhang, Yan,Xu, Yong,Ding, Ke

supporting information, p. 767 - 772 (2019/05/08)

A series of (E)-3-(4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyanoacrylamide derivatives were designed and synthesized as new estrogen-related receptor α (ERRα) degraders based on the proteolysis targeting chimera (PROTAC) concept. One of the representative compounds 6c is capable of specifically degrading ERRα protein by >80% at a relatively low concentration of 30 nM, becoming one of the most potent and selective ERRα degraders to date. Compound 6c could be utilized as a new powerful research tool for further biological investigation of ERRα.

CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY

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Page/Page column 46, (2011/05/06)

Compounds of formula (I) having activities at muscarinic and β2-receptors (MABAs) for use in therapy.

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