1260093-87-5Relevant academic research and scientific papers
A straightforward route to novel α,α-disubstituted tetrahydrofuran β-amino acids and spirodiketopiperazines from sugar lactones
Soengas, Raquel G.
, p. 2549 - 2552 (2010)
Indium-mediated Reformatsky reactions of aldonolactones with ethyl α-bromoisobutyrate allowed the synthesis of ulosonic acid esters, which were readily transformed into the corresponding tetrahydrofuran β-azido esters in a stereoselective fashion. This approach provided monomeric components suitable for oligomerization to the carbopeptoid class of foldamers and prompted the total synthesis of the attractive novel spiro diketopiperazine, which can be regarded as a spironucleoside. Georg Thieme Verlag Stuttgart New York.
