1260098-51-8

Basic information

• Product Name: 2-[4-(1-methyl-1H-pyrrole-2-carbonyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone
• CAS NO: 1260098-51-8
• Molecular Weight: 452.597
• Mol File: 1260098-51-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[4-(1-methyl-1H-pyrrole-2-carbonyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(1-methyl-1H-pyrrole-2-carbonyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone(1260098-51-8)
• EPA Substance Registry System: 2-[4-(1-methyl-1H-pyrrole-2-carbonyl)-piperazin-1-yl]-1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-ethanone(1260098-51-8)

Safety Data

• Hazardous Substances Data: 1260098-51-8(Hazardous Substances Data)

Upstream product

• 473733-93-6 tert-butyl 4-(1-methyl-1H-pyrrole-2-carbonyl)piperazine-1-carboxylate 
• 1391636-58-0 C₂₁H₂₆ClN₃O₃ 
• 41720-98-3 (R)-2-methylpyrrolidine hydrochloride 
• 91427-23-5 1-[4-(3-chloropropoxy)phenyl]ethanone 
• 26214-68-6 1-methyl-pyrrole-2-carboxylic acid chloride 
• 99-93-4 4-Hydroxyacetophenone 

Relevant articles and documents

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Optimization of a series of aminomethyl ketone diamine H3R antagonists to reduce the brain exposure by lowering the pKa, led to molecules with improved pharmacokinetic properties. Compounds 9, 19, and 25 had high affinity for human H3R and demonstrated in vivo H3R functional activity in the rat dipsogenia model. Compound 9 displayed modest wake-promoting activity in the rat EEG/EMG model.