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1260099-73-7

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1260099-73-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1260099-73-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,0,9 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1260099-73:
(9*1)+(8*2)+(7*6)+(6*0)+(5*0)+(4*9)+(3*9)+(2*7)+(1*3)=147
147 % 10 = 7
So 1260099-73-7 is a valid CAS Registry Number.

1260099-73-7Downstream Products

1260099-73-7Relevant articles and documents

COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS

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, (2021/10/15)

Bifunctional compounds, which find utility as modulators of Kirsten ras sarcoma protein (KRas or KRAS), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the Von Hippel-Lindau E3 ubiquitin ligase and on the other end a moiety which binds KRas, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The heterobifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

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