1260146-34-6

Upstream product

• 1021306-03-5 C₂₂H₂₈O₂Si 
• 1260146-96-0 C₂₂H₂₆O₂Si 
• 4358-87-6 (RS)-methyl mandelate 
• 611-71-2 MANDELIC ACID 
• 148204-86-8 (tert-butyldimethylsilanyloxy)phenylacetic acid methyl ester 
• 536-74-3 phenylacetylene 
• 163667-14-9 2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 21772-11-2 1,4-diphenylbutan-3-yn-2-one 

Downstream Products

• 1260146-54-0 1-hydroxy-1,4-diphenylbut-3-yne-2-one 
• 127388-13-0 1,4-diphenyl-3-butyne-1,2-dione 

Relevant academic research and scientific papers

PPh3·HBr-DMSO: A Reagent System for Diverse Chemoselective Transformations

The broad applicability of the hitherto unexplored reagent combination PPh3·HBr-DMSO is exemplified with multiple highly diverse one-step transformations to synthetically useful building blocks, such as flavones, 4H-thiochromen-4-ones, α-hydroxy ketones, 1,4-naphthoquinones (including vitamin K3), 2-bromo-3-substituted-1H-1-indenones, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones. The simple and mild reaction conditions make the reagent superior in terms of yield and substrate scope in comparison with the existing alternatives.

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).