1260146-75-5Relevant academic research and scientific papers
2-bit dicarbonyl substituted pyrrole compound and preparation method thereof
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Paragraph 0006; 0014; 0027, (2017/08/27)
The invention discloses a 2-bit dicarbonyl substituted pyrrole compound and a preparation method thereof, and belongs to the technical field of synthesis of pyrrole derivatives. The technical scheme is that the general structural formula of the 2-bit dicarbonyl substituted pyrrole compound is as shown in the specification. According to the preparation method, 2-bit double-carbonylation of pyrrole is achieved by the aid of one-step cascade reaction, a series of multifunctional 2-bit dicarbonyl substituted pyrrole compounds are synthesized, and the preparation method lays a foundation for further derivatization research of the compound and synthesized pharmaceutical molecules containing pyrrole structures.
Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates
Chen, Chien-Tien,Kao, Jun-Qi,Salunke, Santosh B.,Lin, Ya-Hui
, p. 26 - 29 (2011/03/22)
Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).
