1260154-47-9Relevant academic research and scientific papers
Synthesis and microbiological evaluation of mannich bases derived from 4,6-diacetylresorcinol
Husain, Asif,Maaz, Mohammad,Ansari, Khursheed Ahmad,Ahmad, Ausaf,Rashid, Mohd.
, p. 332 - 334 (2010)
In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as 1H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 μg/mL were used as standard drugs for antibacterial and antifungal activities, respectively.
New 4,6-diacetyl resorcinol Mannich bases: Synthesis and biological evaluation
Khan, Mohammed Sardaryar,Husain, Asif,Sharma, Sanjay
experimental part, p. 261 - 266 (2011/07/09)
In the present study, a series of Mannich bases was synthesized by condensing 4,6-diacetylresorcinol with formaldehyde and some selected secondary amines following the Mannich reaction conditions. Findings revealed that Mannich reaction did not take place at the acetyl function but occurred on the aromatic ring position between the two hydroxyl groups. It was also observed that in one case instead of the desired base (3a), the dimer (4) of the starting material (4,6-diacetylresorcinol) having a methylene bridge could be isolated. The newly synthesized compounds were characterized on the basis of elemental analysis as well as 1H NMR and mass spectral data. The products have been evaluated for antiinflammatory, ulcerogenic and lipid peroxidation actions with some significant results.
