126016-01-1Relevant academic research and scientific papers
Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4-thiadiazole analogs
Varvaresou, Athanasia,Tsantili-Kakoulidou, Anna,Siatra-Papastaikoudi, Theodora,Tiligada, Ekaterini
, p. 48 - 54 (2007/10/03)
New indolic derivatives of thiosemicarbazides and some cyclic 1,2,4- triazol-5-thione analogs were synthesized. The newly synthesized compounds as well as some indole containing thiosemicarbazides, 1,2,4-triazoles and 1,3,4- thiadiazoles, which have been reported previously, were investigated for antimicrobial, antifungal and antiphage activity. Certain thiosemicarbazide derivatives and the corresponding cyclic 1,2,4-triazole analogs showed selective antimicrobial or antifungal activity, while they lack any antiphage activity. Antiphage activity was detected for one compound, bearing the 1,3,4-thiadiazole nucleus. The selectively active compounds cover a wide range of lipophilicity. Structure-activity relations show a remarkably similarity in the antimicrobial and antifungal behaviour of the thiosemicarbazides and their cyclic triazo-thien-5-yl analogs, while α- naphtyl substitution in the non indolic portion of the molecule is favorable. C5 substitution on the indolic nucleus may also be critical for selective activity.
Synthesis of oxadiazolyl-, thiadiazolyl- and triazolylindoles and indolylthiazolidinones
Hiremath, S. P.,Sonar, V. N.,Raja Sekhar, K.,Purohit, M. G.
, p. 626 - 630 (2007/10/02)
Ethyl substituted indole-2-carboxylates (1a-n) are reacted with hydrazine hydrate to get the corresponding carbohydrazides (2a-n).These hydrazides are condensed with phenyl isothiocyanate to get 1-phenyl-3-(substituted indole-2'-carboxamido)thioureas (3a-
