126016-01-1

Basic information

• Product Name: N₁-phenyl-2-[(5-chloro-1H-2-indolyl)carbonyl]-1-hydrazinecarbothioamide
• Synonyms: N₁-phenyl-2-[(5-chloro-1H-2-indolyl)carbonyl]-1-hydrazinecarbothioamide
• CAS NO: 126016-01-1
• Molecular Weight: 344.824
• Mol File: 126016-01-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N₁-phenyl-2-[(5-chloro-1H-2-indolyl)carbonyl]-1-hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N₁-phenyl-2-[(5-chloro-1H-2-indolyl)carbonyl]-1-hydrazinecarbothioamide(126016-01-1)
• EPA Substance Registry System: N₁-phenyl-2-[(5-chloro-1H-2-indolyl)carbonyl]-1-hydrazinecarbothioamide(126016-01-1)

Safety Data

• Hazardous Substances Data: 126016-01-1(Hazardous Substances Data)

Upstream product

• 20948-67-8 5-chloro-1H-indole-2-carbohydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 126016-50-0 3-(5'-chloro-indole-2'-carboxamido)-2-phenylimino-4-thiazolidinone 
• 126016-22-6 5-chloro-2-(5'-phenylamino-1',3',4'-thiadiazol-2'-yl)indole 
• 126016-08-8 5-(5-chloro-1H-indol-2-yl)-N-phenyl-1,3,4-oxadiazol-2-amine 
• 126016-36-2 5-chloro-2-(5'-mercapto-4'-phenyl-1',2',4'-triazol-3'-yl)indole 

Relevant articles and documents

Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4-thiadiazole analogs

New indolic derivatives of thiosemicarbazides and some cyclic 1,2,4- triazol-5-thione analogs were synthesized. The newly synthesized compounds as well as some indole containing thiosemicarbazides, 1,2,4-triazoles and 1,3,4- thiadiazoles, which have been reported previously, were investigated for antimicrobial, antifungal and antiphage activity. Certain thiosemicarbazide derivatives and the corresponding cyclic 1,2,4-triazole analogs showed selective antimicrobial or antifungal activity, while they lack any antiphage activity. Antiphage activity was detected for one compound, bearing the 1,3,4-thiadiazole nucleus. The selectively active compounds cover a wide range of lipophilicity. Structure-activity relations show a remarkably similarity in the antimicrobial and antifungal behaviour of the thiosemicarbazides and their cyclic triazo-thien-5-yl analogs, while α- naphtyl substitution in the non indolic portion of the molecule is favorable. C5 substitution on the indolic nucleus may also be critical for selective activity.