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CAS

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1260225-12-4

2-cyclobutyl-5-hydroxyisoindolin-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1260225-12-4 Structure

  • Basic information

    1. Product Name: 2-cyclobutyl-5-hydroxyisoindolin-1-one
    2. Synonyms: 2-cyclobutyl-5-hydroxyisoindolin-1-one
    3. CAS NO:1260225-12-4
    4. Molecular Formula:
    5. Molecular Weight: 203.241
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1260225-12-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-cyclobutyl-5-hydroxyisoindolin-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-cyclobutyl-5-hydroxyisoindolin-1-one(1260225-12-4)
    11. EPA Substance Registry System: 2-cyclobutyl-5-hydroxyisoindolin-1-one(1260225-12-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1260225-12-4(Hazardous Substances Data)

1260225-12-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1260225-12-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,2,2 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1260225-12:
(9*1)+(8*2)+(7*6)+(6*0)+(5*2)+(4*2)+(3*5)+(2*1)+(1*2)=104
104 % 10 = 4
So 1260225-12-4 is a valid CAS Registry Number.

1260225-12-4Upstream product

1260225-12-4Downstream Products

1260225-12-4Relevant articles and documents

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

Dhanya, Raveendra-Panickar,Sidique, Shyama,Sheffler, Douglas J.,Nickols, Hilary Highfield,Herath, Ananda,Yang, Li,Dahl, Russell,Ardecky, Robert,Semenova, Svetlana,Markou, Athina,Conn, P. Jeffrey,Cosford, Nicholas D. P.

, p. 342 - 353 (2011)

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3- dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with optimized potency and superior druglike properties. These analogues are more potent than 1 in vitro and are highly selective for mGluR2 vs other mGluR subtypes. They have significantly improved pharmacokinetic (PK) properties, with excellent oral bioavailability and brain penetration. The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.

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