1260383-51-4

Basic information

• Product Name: 4-fluoro-2-Methyl-1h-indole
• Synonyms: 4-fluoro-2-Methyl-1h-indole
• CAS NO: 1260383-51-4
• Molecular Formula: C₉H₈FN
• Molecular Weight: 149.1649232
• Mol File: 1260383-51-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 269.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.97±0.30(Predicted)
• CAS DataBase Reference: 4-fluoro-2-Methyl-1h-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-Methyl-1h-indole(1260383-51-4)
• EPA Substance Registry System: 4-fluoro-2-Methyl-1h-indole(1260383-51-4)

Safety Data

• Hazardous Substances Data: 1260383-51-4(Hazardous Substances Data)

Usage

General Description

4-fluoro-2-methyl-1H-indole is a chemical compound with the molecular formula C9H8FN. It is a derivative of indole, a heterocyclic aromatic compound. This chemical has a fluorine atom and a methyl group attached to the indole ring, giving it unique properties and potential applications in the field of organic synthesis and pharmaceutical research. It is commonly used as a building block in the synthesis of various biologically active compounds, including pharmaceutical drugs and agrochemicals. The compound's structure and reactivity make it a valuable tool for the creation of new chemical entities with potential therapeutic and agricultural applications. Overall, 4-fluoro-2-methyl-1H-indole is an important and versatile chemical in the realm of organic chemistry and drug discovery.

Upstream product

• 1354699-91-4 4-fluoro-2-methyl-1-phenylsulfonyl-1H-indole 
• 102855-23-2 4-fluoro-1-(phenylsulfonyl)-1H-indole 
• 443-86-7 3-fluoro-2-methylaniline 
• 129822-38-4 tert-butyl (3-fluoro-2-methylphenyl)carbamate 
• 1383976-61-1 tert-butyl [3-fluoro-2-(2-oxopropyl)phenyl]carbamate 
• 387-43-9 4-fluoroindole 
• 6921-22-8 1,2-difluoro-3-nitrobenzene 

Downstream Products

• 1354699-89-0 1-[2'-deoxy-β-D-erythro-pentofuranosyl]-4-fluoro-2-methylindole 
• 1354699-93-6 1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-4-fluoro-2-methylindole 
• 1354699-92-5 1-[2'-deoxy-3',5'-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-4-fluoro-2-methylindole 
• 1542705-08-7 N-benzyl-2-(4-fluoro-2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine 

Relevant articles and documents

4-chloro-2-methylindole and preparation method and application thereof

The invention discloses a new compound 4-chloro-2-methylindole and a preparation method and application thereof. The structure of the 4-chloro-2-methylindole is shown as a formula 1, 2,3-difluoronitrobenzene is used as a raw material, and the 4-chloro-2-methylindole is obtained through substitution, protection, reduction and cyclization. The product new compound 4-chloro-2-methylindole can be stably obtained based on a synthetic route and reaction conditions, and side reaction is avoided. In addition, the used raw material is commonly and easy to obtain, the reaction conditions are mild, and the requirements for experimental facilities are not high. The new compound 4-chloro-2-methylindole with its chemical structure makes derived medicines and pesticides have unique physiological activity, and can serve a novel efficient medicine and pesticide intermediate.

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.