1260585-14-5

Basic information

• Product Name: 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
• Synonyms: 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one;2-hydroxy-8-(trifluoromethyl)-7,8-dihydro-1H-pyrimido[1,2-a]pyrimidin-4(6H)-one;2-Hydroxy-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one
• CAS NO: 1260585-14-5
• Molecular Formula: C8H8F3N3O2
• Molecular Weight: 235.17
• Mol File: 1260585-14-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one(1260585-14-5)
• EPA Substance Registry System: 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one(1260585-14-5)

Safety Data

• Hazardous Substances Data: 1260585-14-5(Hazardous Substances Data)

Upstream product

• 16075-42-6 2-amino-4-trifluoromethylpyrimidine 
• 105-53-3 diethyl malonate 

Downstream Products

• 1260585-32-7 (8S)-9-[(1R)-1-(4-bromophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-70-3 (8S)-9-[2-(3-chlorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-60-1 (8S)-9-[2-(3-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-59-8 (8S)-9-[(1R and 1S)-1-(2-fluorophenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-58-7 (8S)-2-(morpholin-4-yl)-8-(trifluoromethyl)-9-[4-(trifluoromethyl)phenyl]-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-57-6 (8S)-9-(4-chlorophenyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-56-5 (8S)-9-(3-methylphenyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-49-6 (8S)-9-(4-methoxyphenyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-47-4 (8S)-9-[2-(3-methoxyphenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-46-3 (8S)-9-[2-(2-methoxyphenyl)ethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-44-1 (8S)-9-(2-chlorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-40-7 (S)-9-benzoyl-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one 
• 1260585-39-4 (8S)-9-(4-fluorobenzyl)-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 
• 1260585-09-8 (S)-9-[2-(4-methoxyphenyl)ethyl]-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

New 6, 7, 8, 9-tetrahydropyrimido {1, 2-a} pyrimidinecarboxylic-4-onederivative, medicinal use and preparation thereof

The invention relates to compounds of the formula: or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.

PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF

The invention relates to novel products of formula (Ia) or (Ib): these products being in all the isomeric forms and salts as drugs, notably as anticancer drugs.