1260598-07-9

Upstream product

• 645-13-6 4-isopropylacetophenone 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 852814-99-4 ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate 
• 659-28-9 p-trifluoromethoxybenzaldehyde 

Downstream Products

• 1384877-99-9 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-phenylthiopyridazin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-2(5H)-one 
• 1384877-98-8 3-hydroxy-1-(6-methylthiopyridazin-3-yl)-4-(4-isopropylbenzoyl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-2(5H)-one 
• 1384878-00-5 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-(2-methoxyethoxy)pyridazin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-2(5H)-one 
• 1384878-01-6 1-(6-ethynylpyridazin-3-yl)-3-hydroxy-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one 
• 1260598-08-0 3-hydroxy-4-(4-isopropyl-benzoyl)-1-[6-(4-nitro-phenylsulfanyl)pyridazin-3-yl]-5-(4-trifluoromethoxy-phenyl)-1,5-dihydro-pyrrol-2-one 

Relevant academic research and scientific papers

1-(6-MEMBERED AZO-HETEROCYCLIC)-2,5-DIHYDRO-1H-PYRROL-2-ONE DERIVATIVES AS ANTI-HEPATITIS C VIRUS, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns 1-(6-memberedazo-heterocyclic)-2,5-dihydro–1H–pyrrol–2-one compoundsof the following formula (I) or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C virus.

1-(6 MEMBERS AZO-HETEROCYCLIC)-PYRROLIN-2-ONE COMPOUNDS AS INHIBITORS OF HEPATITIS C NS5B POLYMERASE, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns a l-(6 members azo-heterocyclic)-pyrrolin-2-one compound of the following formula I or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C NS5B polymerase.