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1260653-09-5

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1260653-09-5 Usage

General Description

The chemical 1-(2,3-Dimethylphenyl)-6,7-dihydro-1H-indazol-4(5H)-one is a heterocyclic compound with a fused indazole and cyclopentanone ring system. It is a derivative of indazole, a nitrogen-containing aromatic heterocycle, and is substituted with a 2,3-dimethylphenyl group at the 1-position. 1-(2,3-Dimethylphenyl)-6,7-dihydro-1H-indazol-4(5H)-one has potential pharmaceutical applications and may exhibit biological activities due to its structural features. Further research on this chemical may reveal its potential as a drug candidate or lead compound for the development of new pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 1260653-09-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,6,5 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1260653-09:
(9*1)+(8*2)+(7*6)+(6*0)+(5*6)+(4*5)+(3*3)+(2*0)+(1*9)=135
135 % 10 = 5
So 1260653-09-5 is a valid CAS Registry Number.

1260653-09-5Downstream Products

1260653-09-5Relevant articles and documents

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and in Vitro Metabolic Stability

Popova, Gergana,Ladds, Marcus J. G. W.,Johansson, Lars,Saleh, Aljona,Larsson, Johanna,Sandberg, Lars,Sahlberg, Sara H?ggblad,Qian, Weixing,Gullberg, Hjalmar,Garg, Neeraj,Gustavsson, Anna-Lena,Haraldsson, Martin,Lane, David,Yngve, Ulrika,Lain, Sonia

, p. 3915 - 3934 (2020/05/27)

Human dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo pyrimidine synthesis pathway, is a target for the treatment of rheumatoid arthritis and multiple sclerosis and is re-emerging as an attractive target for cancer therapy. Here we describe the optimization of recently identified tetrahydroindazoles (HZ) as DHODH inhibitors. Several of the HZ analogues synthesized in this study are highly potent inhibitors of DHODH in an enzymatic assay, while also inhibiting cancer cell growth and viability and activating p53-dependent transcription factor activity in a reporter cell assay. Furthermore, we demonstrate the specificity of the compounds toward the de novo pyrimidine synthesis pathway through supplementation with an excess of uridine. We also show that induction of the DNA damage marker γ-H2AX after DHODH inhibition is preventable by cotreatment with the pan-caspase inhibitor Z-VAD-FMK. Additional solubility and in vitro metabolic stability profiling revealed compound 51 as a favorable candidate for preclinical efficacy studies.

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