1260663-37-3

Basic information

• Product Name: 4,8-dichloropyrido[3,4-d]pyriMidine
• Synonyms: 4,8-dichloropyrido[3,4-d]pyriMidine
• CAS NO: 1260663-37-3
• Molecular Formula: C7H3Cl2N3
• Molecular Weight: 200.02482
• Mol File: 1260663-37-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 354.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.573±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 0.21±0.30(Predicted)
• CAS DataBase Reference: 4,8-dichloropyrido[3,4-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,8-dichloropyrido[3,4-d]pyriMidine(1260663-37-3)
• EPA Substance Registry System: 4,8-dichloropyrido[3,4-d]pyriMidine(1260663-37-3)

Safety Data

• Hazardous Substances Data: 1260663-37-3(Hazardous Substances Data)

Usage

General Description

The chemical 4,8-dichloropyrido[3,4-d]pyrimidine is a heterocyclic compound with a molecular formula C8H4Cl2N4. It is a type of pyrimidine compound, which is commonly found in nucleic acids such as DNA and RNA. This chemical is known for its potential use in pharmaceuticals and agrochemicals, as it has been studied for its antiviral and anticancer properties. Additionally, it can be used as a building block in the synthesis of various organic compounds. Its structural and chemical properties make it a versatile and important molecule in the fields of medicine and chemistry.

Upstream product

• 173435-41-1 methyl 3-amino-2-chloropyridine-4-carboxylate 
• 84341-13-9 8-chloro-3H-pyrido [3 ,4-d]pyrimidin-4-one 
• 58483-94-6 3-amino-2-chloroisonicotinic acid 
• 1312105-89-7 3-((tert-butoxycarbonyl)amino)-2-chloroisonicotinic acid 
• 209798-48-1 tert-butyl N-(2-chloro-3-pyridinyl)carbamate 
• 6298-19-7 2-chloro-3-aminopyridine 

Relevant articles and documents

NAPHTHYRIDINE DERIVATIVES AS PRC2 INHIBITORS

Disclosed are compounds of formula (I) or (II) that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors

A highly ligand efficient, novel 8-oxo-pyridopyrimidine containing inhibitor of Jak1 and Jak2 isoforms with a pyridone moiety as the hinge-binding motif was discovered. Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the molecule was adjusted to gain cellular activity. The crystal structures of two representative inhibitors bound to Jak1 were obtained to enable SAR exploration.