126067-60-5 Usage
General Description
5-Methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid is a chemical compound with the molecular formula C11H9F3N2O2. It is a pyrazole derivative and contains a carboxylic acid functional group. 5-Methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid is a synthetic intermediate used in the pharmaceutical industry for the production of various drugs. The trifluoromethyl substituent on the phenyl ring enhances the compound's pharmacological properties, making it a valuable building block in medicinal chemistry. Additionally, the presence of the carboxylic acid group allows for further functionalization and modification of the molecule, making it an important tool in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 126067-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,0,6 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 126067-60:
(8*1)+(7*2)+(6*6)+(5*0)+(4*6)+(3*7)+(2*6)+(1*0)=115
115 % 10 = 5
So 126067-60-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H9F3N2O2/c1-7-5-10(11(18)19)16-17(7)9-4-2-3-8(6-9)12(13,14)15/h2-6H,1H3,(H,18,19)
126067-60-5Relevant articles and documents
Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity
Kordik, Cheryl P.,Luo, Chi,Zanoni, Brian C.,Lovenberg, Timothy W.,Wilson, Sandy J.,Vaidya, Anil H.,Crooke, Jeffrey J.,Rosenthal, Daniel I.,Reitz, Allen B.
, p. 2287 - 2290 (2007/10/03)
1-Aryl-3-carboxamido-5-alkylpyrazoles were prepared based on a hit found in high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. 1-(3-Trifluoromethylphenyl)-3-[N-(5-quinolinyl)carboxamido]-5-methylpyrazole (31) bound to the human neuropeptide Y5 receptor with a 80 nM IC50and was shown to inhibit cumulative food consumption 43.2% 2-6 h after ip dosing in a fasting-induced feeding model in rats.
