1260670-71-0

Basic information

• Product Name: (5-(trifluoroMethyl)thiophen-2-yl)Methanol
• Synonyms: (5-(trifluoroMethyl)thiophen-2-yl)Methanol;[5-(TRIFLUOROMETHYL)THIEN-2-YL]METHANOL
• CAS NO: 1260670-71-0
• Molecular Formula: C₆H₅F₃OS
• Molecular Weight: 182.1635096
• Mol File: 1260670-71-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 195.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.442±0.06 g/cm3(Predicted)
• PKA: 13.56±0.10(Predicted)
• CAS DataBase Reference: (5-(trifluoroMethyl)thiophen-2-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-(trifluoroMethyl)thiophen-2-yl)Methanol(1260670-71-0)
• EPA Substance Registry System: (5-(trifluoroMethyl)thiophen-2-yl)Methanol(1260670-71-0)

Safety Data

• Hazardous Substances Data: 1260670-71-0(Hazardous Substances Data)

Usage

General Description

The chemical (5-(trifluoroMethyl)thiophen-2-yl)Methanol is a compound with the molecular formula C8H7F3OS. It is an organosulfur compound that contains a thiophene ring with a trifluoromethyl group and a hydroxyl group attached to it. (5-(trifluoroMethyl)thiophen-2-yl)Methanol is commonly used as an intermediate in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and agrochemicals due to its unique structure and reactivity. Additionally, it is also used as a building block in the synthesis of various fine and specialty chemicals. However, it is important to note that this compound should be handled and used with care, following proper safety precautions and guidelines.

Upstream product

• 672-38-8 6-(trifluoromethyl)-2H-thiopyran 
• 128009-32-5 5-(trifluoromethyl)thiophene-2-carboxylic acid 

Relevant articles and documents

Sulfur-assisted ring contraction of polyfluoroalkylthiopyran derivatives as a route to functionalized fluorine-containing thiophenes

A synthetic route to functionalized α-(polyfluoroalkyl)thiophenes based on the reactions of ring contraction of polyfluoroalkyl substituted thiopyran derivatives has been explored. Potent 6-membered precursors for the preparation of thiophenes were obtained by the addition of bromine to the double bonds of 2-chloro-2-(trifluoromethyl)-3,6-dihydro-2H-tetrahydrothiopyran and 6-(polyfluoroalkyl)-2H-thiopyrans. The reactions of the resulted 4,5-dibromo-2-chloro-2-(trifluoromethyl)tetrahydrothiopyrans and trans-3,4-dibromo-6-(polyfluoroalkyl)-3,4-dihydro-2H-thiopyrans with sodium acetate in acetic acid produced 2-(acetoxymethyl)-5-(polyfluoroalkyl)thiophenes. Base-catalyzed methanolysis of the acetoxymethyl derivatives allowed preparing the corresponding 2-(hydroxymethyl)-5-(polyfluoroalkyl)thiophenes. The mechanism, which includes formation and nucleophilic cleavage of thiiranium cations, has been suggested for the transformation of dibromothiopyran derivatives to substituted thiophenes.

Triazinone compound and T-type calcium channel inhibitor

There is provided a novel triazinone compound that has an excellent T-type voltage-dependent calcium channel inhibitory activity and is specifically useful for treatment of pain. A compound of Formula (I), a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof: where each substituent is defined in detail in the description or claims, for example R1 is H or C1-6 alkoxy, etc., each of L1 and L2 is independently a single bond or NR2, etc., L3 is C1-6 alkylene, etc., A is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc., B is C3-11 cycloalkylene, etc., D is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc.