1260676-83-2

Upstream product

• 93587-26-9 7-nitro-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one 

Downstream Products

• 1415565-38-6 N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)benzamide 
• 1415565-39-7 N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorobenzamide 
• 1415565-40-0 N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide 
• 1415565-41-1 N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide 
• 1415565-17-1 4-([1,1'-biphenyl]-4-yloxy)-7-nitro-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine 
• 1415565-50-2 tert-butyl ((1r,4r)-4-((4-(benzyl(ethyl)amino)-7-nitro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl)cyclohexyl)carbamate 
• 1415565-51-3 tert-butyl ((1r,4r)-4-((7-amino-4-(benzyl(ethyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl)cyclohexyl)carbamate 
• 1415565-52-4 C₃₅H₄₄N₆O₄ 
• 1415565-53-5 C₂₈H₃₈N₆O₄ 
• 1415565-54-6 N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide 
• 1415565-22-8 4-([1,1'-biphenyl]-4-yloxy)-7-nitro-5H-pyrrolo[3,2-d]pyrimidine 
• 1415565-18-2 7-nitro-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine 
• 1415565-19-3 4-(4-methoxyphenoxy)-7-nitro-5H-pyrrolo[3,2-d]pyrimidine 
• 1415565-20-6 4-(3-methoxyphenoxy)-7-nitro-5H-pyrrolo[3,2-d]pyrimidine 

Relevant academic research and scientific papers

Efficient solution-phase synthesis of 4,5,7-trisubstituted pyrrolo[3,2- d ]pyrimidines

We have developed an efficient and robust route to synthesize 4,5,7-trisubstituted pyrrolo[3,2-d]pyrimidines as potent kinase inhibitors. This solution-phase synthesis features a SNAr substitution reaction, cross-coupling reaction, one-pot reduction/reductive amination and N-alkylation reaction. These reactions occur rapidly with high yields and have broad substrate scopes. A variety of groups can be selectively introduced into the N5 and C7 positions of 4,5,7-trisubstituted pyrrolopyrimidines at a late stage of the synthesis, thereby providing a highly efficient approach to explore the structure-activity relationships of pyrrolopyrimidine derivatives. Four synthetic analogs have been profiled against a panel of 48 kinases and a new and selective FLT3 inhibitor 9 is identified.