126070-10-8Relevant articles and documents
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Noguchi, Tomomi,Sano, Hiroko,Shimazawa, Rumiko,Tanatani, Aya,Miyachi, Hiroyuki,Hashimoto, Yuichi
, p. 4141 - 4145 (2007/10/03)
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.