126070-14-2Relevant academic research and scientific papers
Photochemical synthesis of benzoxazolo[3,2-b]isoquinolin-11-one and isoquinolino[3,2-b][1,3]benzoxazin-11-one under basic conditions
Senthilvelan,Thirumalai,Ramakrishnan
, p. 4213 - 4220 (2005)
Irradiation of N-phenyl substituted isoquinolines in acetonitrile containing 1 M NaOH in a multilamp reactor (MLR) furnished benzoxazolo[3,2-b] isoquinolin-11-ones. In contrast, irradiation of the N-benzyl substituted isoquinoline derivative under the sam
A new photochemical synthesis of benzoxazolo[3,2-b]isoquinolin-11-one and isoquinolino[3,2-b][1,3]benzoxazin-11-one
Senthilvelan, Annamalai,Ramakrishnan, Vayalakkavoor T.
, p. 8379 - 8381 (2007/10/03)
Photocyclization of substituted tetrahydroisoquinoline-1,3-diones, under base-mediated conditions, afforded benzoxazolo[3,2-b]isoquinolin-11-ones and an isoquinolino[3,2-b]benzoxazin-11-one.
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: Identification of the target molecule and a structure-activity relationship study
Komoda, Masato,Kakuta, Hiroki,Takahashi, Hiroyasu,Fujimoto, Yasuyuki,Kadoya, Shizuo,Kato, Fuminori,Hashimoto, Yuichi
, p. 121 - 131 (2007/10/03)
2-(2,6-Diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (2: PIQ-22) was found to be a potent and specific inhibitor of puromycin-sensitive aminopeptidase (PSA). Lineweaver-Burk plot analysis showed that PSA is inhibited by PIQ-22 in a non-competitive manner. Structure-activity relationship studies indicated that tautomerism of the imidobenzoylketone group in the cyclic imide moiety of the PIQ-22 skeleton is important for the inhibitory activity.
2-BENZENEACETIC ACIDS AFFECTING ROOT GRAVITROPISM
Modena, T.,Azzolina, O.,Genta, I.,Mazza, M.
, p. 721 - 730 (2007/10/02)
A series of new 2-benzeneacetic acids , prepared by basic hydrolysis of 2-substituted 1,3(2H-4H)isoquinolinediones, were studied from the point of view of their antigravitropic activity on germinating seeds of Lens esculenta Moench.The results of the assay showed that the class possesses antigravitropic activity.The most active compounds were the dichlorosubstituted phenyl-derivatives (XXI), (XVII) and (XX), 2-naphthyl- (XXIV), 8-quinolyl- (XXV) and 4-biphenylyl- (IX) derivatives.The activity of the class is generally lower than that of the the homologous N-arylphthalamic acids.Moreover the trifluoromethyl-phenyl- (III) and the 1-naphthyl- (XXIII) derivatives, subjected to herbicidal assay against some common weeds, showed a noticeable activity, with marked selectivity against Dicotyledons.
