1260767-61-0Relevant articles and documents
Strain-release arylations for the bis-functionalization of azetidines
Aicher, Julian,Apaloo-Messan, Kodjo-Edmond,Didier, Dorian,Jiang, Dongfang,Ni?l, Benedikt,Reiners, Felix,Shahbaz, Muhammad,Trauner, Florian
supporting information, p. 2564 - 2567 (2022/03/03)
The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings.
Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines
Wang, Zhaobin,Sheong, Fu Kit,Sung, Herman H. Y.,Williams, Ian D.,Lin, Zhenyang,Sun, Jianwei
supporting information, p. 5895 - 5898 (2015/05/27)
The first catalytic asymmetric desymmetrization of azetidines is disclosed. Despite the low propensity of azetidine ring opening and challenging stereocontrol, smooth intermolecular reactions were realized with excellent efficiency and enantioselectivity.
PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS
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Paragraph 0524, (2014/09/29)
The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
PYRIMIDINES AS SODIUM CHANNEL BLOCKERS
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Page/Page column 180; 181, (2013/03/28)
The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
