1260793-84-7

Basic information

• Product Name: 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester
• Synonyms: 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester;EOS-60880
• CAS NO: 1260793-84-7
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.21966
• Mol File: 1260793-84-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester(1260793-84-7)
• EPA Substance Registry System: 1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester(1260793-84-7)

Safety Data

• Hazardous Substances Data: 1260793-84-7(Hazardous Substances Data)

Usage

Derivative of imidazole and isopropylcarboxylic acid

This compound is derived from two different parent molecules, imidazole (a heterocyclic aromatic organic compound) and isopropylcarboxylic acid (a variant of carboxylic acid), which contribute to its unique properties and reactivity.

Pharmaceutical industry use

The compound is commonly used as an intermediate in the synthesis of various drugs, making it an important building block in the creation of pharmaceutical products.

Potential use as a ligand

1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester can act as a ligand in coordination chemistry, meaning it can bind to metal ions to form coordination complexes, which can have various applications in materials science and catalysis.

Building block for organic compounds

The compound can be used as a starting material for the preparation of various organic compounds, making it a versatile chemical for synthetic chemistry.

Ethyl ester group

The presence of an ethyl ester group on the carboxylic acid moiety of the compound imparts lipophilicity (fat solubility) to the molecule, which can affect its solubility and permeability characteristics in biological systems.

Solubility and permeability

The ethyl ester group's lipophilicity can influence the compound's solubility in organic solvents and its ability to pass through cell membranes, which is important for drug delivery and absorption.

Versatility

1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester is a versatile chemical due to its various applications in the synthesis of pharmaceutical and organic compounds, as well as its potential use in coordination chemistry.

Upstream product

• 87951-12-0 3-Dimethylamino-2-isocyanacrylsaeure-ethylester 
• 75-31-0 isopropylamine 
• 2999-46-4 Ethyl isocyanoacetate 
• 72130-97-3 ((Z)-2-N,N-dimethylamino-1-ethoxycarbonyl-vinyl)-methylidyne-ammonium 

Downstream Products

• 1331755-38-4 4-(tert-Butyldiphenylsilyloxymethyl)-1-isopropyl-1H-imidazole 
• 1448870-05-0 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid 
• 1448870-06-1 2-bromo-5-[(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1 H-imidazole-4-carboxylic acid ethyl ester 
• 1448870-08-3 2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1 H-imidazole-4-carboxylic acid 
• 1448870-09-4 2-bromo-5-[(3-chloro-2-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1448870-11-8 2-bromo-5-[(3-chloro-4-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid 
• 1448870-12-9 2-bromo-5-[(3-chloro-4-fluoro-phenylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1448869-68-8 2-bromo-5-[(4-chlorophenyl)-hydroxy-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1448866-68-9 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-2-(4-methoxy-2-methylamino-pyrimidin-5-yl)-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-70-3 C₂₉H₂₈Cl₂N₄O₂ 
• 1448866-71-4 3-[5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-2-yl]-4-ethyl-benzonitrile 
• 1448866-73-6 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-74-7 2-(2-amino-4-methoxy-pyrimidin-5-yl)-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 
• 1448866-75-8 5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-{2-[(2-hydroxy-ethyl)-methyl-amino]-4-methoxy-pyrimidin-5-yl}-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one 

Relevant articles and documents

IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

IMIDAZOPYRROLIDINONE COMPOUNDS

The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.