1260847-43-5

Basic information

• Product Name: (R)-2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (R)-2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1260847-43-5
• Molecular Weight: 300.761
• Mol File: 1260847-43-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester(1260847-43-5)
• EPA Substance Registry System: (R)-2-(2-chloro-5-fluoropyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester(1260847-43-5)

Safety Data

• Hazardous Substances Data: 1260847-43-5(Hazardous Substances Data)

Upstream product

• 884494-36-4 3‐bromo‐2‐chloro‐5‐fluoropyridine 
• 86953-79-9 tert-butyl pyrrolidine-1-carboxylate 

Relevant articles and documents

Pyrazolopyrimidine macrocyclic derivative and application thereof

The invention relates to a novel pyrazolopyrimidine macrocyclic derivative as well as a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrazolopyrimidine macrocyclic derivative as shown in a general formula (I), a preparation method thereof, and application of the pyrazolopyrimidine macrocyclic derivative or a pharmaceutical composition containing the derivative as a therapeutic agent, especially as a tropomyosin-related kinase (TRK) inhibitor, in treatment or prevention of TRK-mediated related diseases such as tumors. Substituents (R1, R2) and groups (X) in the general formula (I) are as defined in the description.