1260862-66-5

Usage

Structure

Pyrimidinol derivative with a fluorophenyl substituent at the 2-position

Potential applications

Medicinal chemistry (pharmaceuticals and agrochemicals)

Biological activity

Antifungal and antiviral agent

Importance in drug discovery

Valuable building block for the synthesis of various biologically active compounds, promising candidate due to its structure and properties, including the potential contribution of the fluorophenyl group to its pharmacokinetic and pharmacodynamic properties.

Upstream product

• 1263188-10-8 5-(ethoxymethoxy)-2-(4-fluorophenyl)pyrimidine 

Downstream Products

• 1263187-33-2 2-({[2-(4-fluorophenyl)-5-pyrimidinyl]oxy}methyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole 
• 1263188-12-0 1-(2-bromo-4-nitro-1H-imidazol-1-yl)-3-{[2-(4-fluorophenyl)-5-pyrimidinyl]oxy}-2-methyl-2-propanol 

Relevant academic research and scientific papers

Amine compound inhibiting SSAO/VAP-1 and application thereof in medicine

The invention relates to an amine compound for inhibiting semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1) and medicinal application thereof, and further relatesto a pharmaceutical composition containing the compound

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Within a backup program for the clinical investigational agent pretomanid (PA-824), scaffold hopping from delamanid inspired the discovery of a novel class of potent antitubercular agents that unexpectedly possessed notable utility against the kinetoplast

NITROIMIDAZOOXAZINE AND NITROIMIDAZOOXAZOLE ANALOGUES AND THEIR USES

The current invention pertains to nitroimidazooxazine and nitroimidazooxazole analogues, their methods of preparation, and uses of the compounds as treatment for Mycobacterium tuberculosis, for use as anti-tubercular drugs, for use as anti-protozoal agents with unexpectedly high potency against Trypanosoma cruzi or Leishmania donovani, and for the treatment of other microbial infections.