1260893-79-5Relevant academic research and scientific papers
Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptides
Koba, Yurie,Hirata, Yoko,Ueda, Atsushi,Oba, Makoto,Doi, Mitsunobu,Demizu, Yosuke,Kurihara, Masaaki,Tanaka, Masakazu
, p. 555 - 562 (2016)
Chiral five-membered carbocyclic ring amino acids bearing various diol acetal moieties were synthesized starting from l-malic acid, and homo-chiral homopeptides composed of cyclic amino acid (S)-Ac5c3EG bearing an ethylene glycol acetal, up to an octapeptide, were prepared. A conformational analysis revealed that (S)-Ac5c3EG homopeptides formed helical structures. (S)-Ac5c3EG homopeptides, up to hexapeptides, formed helical structures without controlling the helical screw direction, while (S)-Ac5c3EG hepta- and octapeptides formed helical structures with a preference for the left-handed (M) helical-screw direction.
