126090-32-2

Basic information

• Product Name: N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride
• Synonyms: N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride
• CAS NO: 126090-32-2
• Molecular Weight: 304.82
• Mol File: 126090-32-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride(126090-32-2)
• EPA Substance Registry System: N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride(126090-32-2)

Safety Data

• Hazardous Substances Data: 126090-32-2(Hazardous Substances Data)

Upstream product

• 126090-31-1 N^α-(tert-butoxycarbonyl)-L-phenylalanine-N-benzyl-N-methylamide 
• 103-67-3 benzyl-methyl-amine 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 131949-86-5 Boc-Lys(Z)-Phe-NMeBzl 
• 126088-74-2 Boc-D-Trp(CHO)-Phe-NMeBzl 
• 150113-36-3 Boc-D-Lys(Z)-Phe-NMeBzl 
• 131949-55-8 Boc-(2S,4R)Hyp-Phe-NMeBzl 
• 131949-63-8 (S)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-azetidine-1-carboxylic acid tert-butyl ester 
• 142800-82-6 (N,N-diethylamino)-β-Ala-Thr-D-Trp(CHO)-Phe-NMeBzl 
• 142800-81-5 H-β-Ala-Thr-D-Trp(CHO)-Phe-NMeBzl 
• 126090-13-9 H-Gly-Thr-D-Trp(CHO)-Phe-NMeBzl*0.3AcOH 
• 126090-58-2 Boc-His(Tos)-D-Trp(CHO)-Phe-NMeBzl 
• 126113-10-8 (S)-2-Amino-pentanedioic acid 1-{[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-amide} 5-dimethylamide; hydrochloride 
• 126090-59-3 (S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride 
• 126089-03-0 Boc-Lys(Z)-D-Trp(CHO)-Phe-NMeBzl 
• 126089-05-2 Boc-Orn(Z)-D-Trp(CHO)-Phe-NMeBzl 
• 126089-17-6 Z-β-Ala-Thr-D-Trp(CHO)-Phe-NMeBzl 

Relevant articles and documents

Studies of Neurokinin Antagonists. 4. Synthesis and Structure-Activity Relationships of Novel Dipeptide Substance P Antagonists: N2--L-prolyl>-N-methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Its Related Compounds

As an extension of our studies on discovering a novel substance P (SP) antagonist, we modified the previously reported dipeptide, N2-2-(1H-indol-3-ylcarbonyl)-L-lysyl>-N-methyl-N-(phenylmethyl)-L-phenylalaninamide (2b).The lysine part in 2b was first optimized to a (2S,4R)-hydroxyproline derivative (3h), which is 2-fold more potent than 2b in SP binding assay using guinea pig lung membranes.Next we modified the 1H-indol-3-ylcarbonyl part in 3h.Introduction of a methyl group at the indole nitrogen enhanced the oral activity, while retaining the binding activity.Finally, we modified the phenylalanine part to culminate in the most potent compound 7k (FK888), which is a potent SP antagonist with NK1 selectivity as well as oral activity.

Studies on Neurokinin Antagonists. 2. Design and Structure-Activity Relationships of Novel Tripeptide Substance P Antagonists, Nα-α-(Nα-Acetyl-L-threonyl)-N1-formyl-D-tryptophyl>-N-methyl-N-(phenylmethyl)-L-ph

Continuing studies on the chemical modification of the previously reported novel tripeptide SP antagonist, Nα-α-α-(tert-butyloxycarbonyl)glutaminyl>-N1-formyl-D-tryptophyl>phenylalanine benzyl ester Boc-Gln