126090-50-4

Upstream product

• 3277-89-2 phenethylmagnesium bromide 
• 33900-01-5 Boc-L-phenylalanine 2-pyridyl ester 
• 1027300-21-5 2-benzyl-4-tert-butoxycarbonylamino-3-oxo-5-phenyl-pentanoic acid allyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 387866-54-8 4(S)-tert-butoxycarbonylamino-3-oxo-5-phenylpentanoic acid allyl ester 

Downstream Products

• 126090-45-7 (S)-2-Amino-1,5-diphenyl-pentan-3-one; hydrochloride 
• 387866-69-5 (1S-benzyl-2R-hydroxy-4-phenylbutyl)carbamic acid 2,2-dimethylpropyl ester 
• 126089-85-8 Boc-D-Trp(CHO)-Phe-CH₂CH₂Ph 
• 126089-41-6 (R)-2-Amino-N-((S)-1-benzyl-2-oxo-4-phenyl-butyl)-3-(1-formyl-1H-indol-3-yl)-propionamide; hydrochloride 
• 126089-86-9 Boc-Gln-D-Trp(CHO)-Phe-CH₂CH₂Ph 

Relevant academic research and scientific papers

DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF

Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. For example, methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some embodiments, comprises providing a reaction mixture including a photoredox catalyst, a transition metal catalyst, a coupling partner and a substrate having a carboxyl group. The reaction mixture is irradiated with a radiation source resulting in cross-coupling of the substrate and coupling partner via a mechanism including decarboxylation, wherein the coupling partner is selected from the group consisting of a substituted aromatic compound and a substituted aliphatic compound.

Highly stereoselective syntheses of syn- and anti-1,2-amino alcohols

The reduction of N-protected amino ketones can be carried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer. Carbamate-protected amino ketones can be reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78°C. N-Trityl-protected amino ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5°C.

Studies on Neurokinin Antagonists. 2. Design and Structure-Activity Relationships of Novel Tripeptide Substance P Antagonists, Nα-α-(Nα-Acetyl-L-threonyl)-N1-formyl-D-tryptophyl>-N-methyl-N-(phenylmethyl)-L-ph

Continuing studies on the chemical modification of the previously reported novel tripeptide SP antagonist, Nα-α-α-(tert-butyloxycarbonyl)glutaminyl>-N1-formyl-D-tryptophyl>phenylalanine benzyl ester Boc-Gln