1260909-26-9Relevant academic research and scientific papers
Asymmetric friedel-crafts alkylation of indole with chalcones catalyzed by chiral phosphoric acids
Scettri, Arrigo,Villano, Rosaria,Acocella, Maria Rosaria
, p. 3030 - 3036 (2009)
The reaction of indole with chalcones, to give Michael-type adducts, was found to occur with good efficiency (up to 98% yield) and moderate enantioselectivity (up to 52% e.e.) in the presence of a chiral BINOL-based phosphoric acid. Furthermore, the alkyl
Chiral Bronsted acid catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones: Short access to optically active 2- and 3-substituted indole derivatives
Sakamoto, Tsubasa,Itoh, Junji,Mori, Keiji,Akiyama, Takahiko
experimental part, p. 5448 - 5454 (2011/01/12)
The asymmetric Friedel-Crafts alkylation reaction of indoles with α,β-unsaturated ketones catalyzed by chiral phosphoric acid is reported. A wide range of indoles and 4,7-dihydroindoles were allowed to react with α,β-unsaturated ketones to give the corres
